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May 1, 1971Cancer

Altered pattern of metastasis following treatment of Ewing's sarcoma with radiotherapy and adjuvant chemotherapy

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Why the study?

Does aggressive adjuvant chemotherapy alter the pattern of metastasis in patients with clinically localized Ewing's sarcoma?

Population

Patients with clinically localized Ewing's sarcoma

Comparison

Aggressive adjuvant systemic chemotherapy… vs Minimal chemotherapy following irradiation

Design

Case_series

Authors

GMGerald W. MarsaProMedica Toledo HospitalRJRalph E. JohnsonGNS Science

Discussion

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Implication

May suggest CNS sanctuary effect after aggressive chemotherapy in Ewing sarcoma; hypothesis-generating and should not change practice.

Structured PICO

Does aggressive adjuvant chemotherapy alter the pattern of metastasis in patients with clinically localized Ewing's sarcoma?

P
Population
Patients with clinically localized Ewing's sarcoma
I
Intervention
Aggressive adjuvant systemic chemotherapy following irradiation of the primary tumor site
C
Comparator
Minimal chemotherapy following irradiation
O
Outcome
Pattern of metastasis (site of dissemination)hard clinical

Aggressive adjuvant chemotherapy for Ewing's sarcoma may suppress systemic metastases but leave the central nervous system unprotected, leading to an altered pattern of CNS metastasis.

Cite This Study

Marsa et al. (1971) studied this question.

synapsesocial.com/papers/6a836dcc8df6316dcba9b60dhttps://doi.org/10.1002/1097-0142(197105)27:5<1051::aid-cncr2820270508>3.0.co;2-7
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Past failures and future possibilities in Ewing's sarcoma:Experimental and preliminary clinical results1969 · 46 citations
  2. 2Ewing's Sarcoma1970 · 49 citations
  3. 3Ewing's sarcoma.Case against surgery1967 · 63 citations
  4. 4Radical radiation therapy and total body irradiation in the treatment of Ewing's Sarcoma1968 · 34 citations