Population
Mice infected with encephalomyocarditis (EMC) virus
Comparison
Prior exposure to whole body X-irradiation vs Non-irradiated control mice
Design
Preclinical
Authors
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Neutralizing antibodies determine EMC virus resistance in mice; leaves open translation to human infections or therapies.
The immunologic response, specifically the elaboration of specific neutralizing antibodies, is a critical determinant of host resistance and viral clearance during primary systemic EMC virus infection in mice.
Murphy et al. (1968) studied this question.
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