Key result
Exposure of normal mouse peritoneal cells to serum from encephalomyocarditis virus-infected mice transferred a hyporeactive state, significantly reducing their interferon response to viral inducers.
A transferable, species-specific hyporeactive factor in the serum of EMC virus-infected mice suppresses interferon production in response to subsequent viral exposure.
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Hyporeactivity transfer via serum may explain blunted interferon responses in viral contexts; leaves open human applicability and therapeutic implications.
Stringfellow et al. (1974) studied Encephalomyocarditis (EMC) virus infection. Serum from EMC virus-infected mice vs. Serum from uninfected mice or normal peritoneal cells was evaluated on Interferon production in response to viral inducers. Exposure of normal mouse peritoneal cells to serum from encephalomyocarditis virus-infected mice transferred a hyporeactive state, significantly reducing their interferon response to viral inducers.
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