May 1, 1970Psychosomatic Medicine

Differential Susceptibility to a Viral Agent in Mice Housed Alone or in Groups

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Why the study?

Does individual housing increase susceptibility to encephalomyocarditis (EMC) virus in mice compared to group housing?

Population

Two strains of mice

Comparison

Individual housing vs Group housing (5 to 20 mice/cage)

Design

Preclinical

Authors

SFStanford B. FriedmanDe Gruyter Brill (Germany)LGLowell A. GlasgowUniversity of Utah RARobert AderOffice of Education

Discussion

Member takes

Implication

Animal data link isolation stress to higher viral susceptibility; leaves open translation to human cardiovascular psychosomatics.

Structured PICO

Does individual housing increase susceptibility to encephalomyocarditis (EMC) virus in mice compared to group housing?

Population

Two strains of mice

Intervention

Individual housing

Comparator

Group housing (5 to 20 mice/cage)

Outcome

Susceptibility to encephalomyocarditis (EMC) virus (mortality)hard clinical

Individual housing in mice increases susceptibility to viral infection, which may be related to elevated stress hormone (corticosterone) levels.

Cite This Study

Friedman et al. (1970) studied this question.

synapsesocial.com/papers/6a907abe33cf5c591c0d61c0 https://doi.org/10.1097/00006842-197005000-00007

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Differential Susceptibility to a Viral Agent in Mice Housed Alone or in Groups

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differential Susceptibility to a Viral Agent in Mice Housed Alone or in Groups

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider