Why the study?
Do sex hormones and adrenal/gonadal status influence susceptibility to encephalomyocarditis virus in mice?
Population
Male, female, and immature mice
Comparison
Castration, adrenalectomy, and administration of… vs Intact mice or untreated controls
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for hormonal modulation of viral susceptibility in animal models.
Do sex hormones and adrenal/gonadal status influence susceptibility to encephalomyocarditis virus in mice?
Testicular, ovarian, and adrenal hormones are critical determinants of susceptibility to encephalomyocarditis virus in mice.
Friedman et al. (1972) studied this question.
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