Key result
In pregnant mice, EMC virus replicated predominantly in the spongiotrophoblast layer of the placenta, with the gestational day 11 group showing the highest sensitivity including fetal myocardial infection.
Population
30 pregnant mice of the BALB/c CrSlc strain
Comparison
Intraperitoneal inoculation with the D variant… vs Intraperitoneal inoculation with 0.1 ml of PBS…
Design
Preclinical
Follow-up
3 days post inoculation
Authors
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Should not change clinical practice; hypothesis-generating for placental viral tropism and gestational timing in fetal myocarditis models.
Pregnant mice are most susceptible to fetal myocardial infection by EMC virus when inoculated on gestational day 11, with the virus replicating predominantly in the spongiotrophoblast layer of the placenta.
Nakayama et al. (2004) studied Encephalomyocarditis (EMC) virus infection (n=30). Encephalomyocarditis virus (EMC-D) inoculation vs. PBS inoculation was evaluated on Fetal mortality. In pregnant mice, EMC virus replicated predominantly in the spongiotrophoblast layer of the placenta, with the gestational day 11 group showing the highest sensitivity including fetal myocardial infection.
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