Why the study?
Does sodium intake alter angiotensin-converting enzyme activity in the brain and aorta of spontaneously hypertensive rats?
Population
Female normotensive Wistar-Kyoto rats, spontaneously hypertensive rats, and stroke-prone SHR, aged 20-21…
Comparison
1.0% NaCl drinking solution for 4 weeks. vs Distilled water ad libitum.
Design
Preclinical
Follow-up
4 weeks
Authors
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Highlights potential brain ACE role in salt-sensitive hypertension models; leaves open translation to human sodium management.
Does sodium intake alter angiotensin-converting enzyme activity in the brain and aorta of spontaneously hypertensive rats?
High sodium intake decreases aortic ACE activity but increases brain ACE activity in spontaneously hypertensive rats, suggesting a localized role of brain ACE in sodium-induced hypertension.
Mizuno et al. (1981) studied this question.
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