Why the study?
No marketed drug exists to block persistent poliovirus excretion in primary immunodeficiency patients, and little data describe medical therapy ending vaccine-derived poliovirus shedding.
Does intravenous gamma globulin interrupt the shedding of vaccine-derived poliovirus in a patient with primary immunodeficiency?
Does intravenous gamma globulin interrupt the shedding of vaccine-derived poliovirus in a patient with primary immunodeficiency?
Intravenous gamma globulin administration may rapidly interrupt the shedding of vaccine-derived poliovirus in patients with primary immunodeficiency.
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May support gamma globulin to interrupt VDPV shedding in immunodeficiency; leaves open need for controlled trials.
Guo et al. (2023) studied this question.
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