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Does the addition of herring sperm DNA reduce the acute cardiotoxic effects of adriamycin and daunorubicin in isolated, perfused rat hearts?
Does the addition of herring sperm DNA reduce the acute cardiotoxic effects of adriamycin and daunorubicin in isolated, perfused rat hearts?
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Binding adriamycin and daunorubicin to DNA reduces their acute cardiotoxicity in an isolated rat heart model.
The acute cardiotoxic effects of adriamycin and daunorubicin have been studied in isolated, perfused rat hearts. Both drugs caused a dose‐dependent decrease in rate and contractile force as well as changes in the ECG indicating a general retardation of impulse propagation. The presence of 0.47 mg/ml of herring sperm DNA in the perfusate greatly reduced the cardiotoxic effect of both drugs. The reduced toxicity is probably due to the binding of the drugs to DNA.
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Langslet et al. (1974) studied this question.
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