Why the study?
Does combination therapy with minoxidil, captopril, and propranolol control severe resistant hypertension?
Does combination therapy with minoxidil, captopril, and propranolol control severe resistant hypertension?
Combination therapy with minoxidil, captopril, and propranolol may be effective for severe resistant hypertension, but requires monitoring for hyperkalemia and acidosis.
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Hypothesis-generating for refractory pediatric hypertension; controlled trials needed before any practice change.
A case of severe hypertension resistant to multiple drug therapy was controlled with minoxidil, captopril, and propranolol hydrochloride after treatment with these drugs alone or in other combinations had failed. Hyperreninemic hypoaldosteronism with hyperkalemia and acidosis developed after captopril administration was started.
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James R. Matson (1981) studied this question.
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