Why the study?
Does combined treatment with minoxidil and captopril improve blood pressure control in patients with severe refractory hypertension?
Does combined treatment with minoxidil and captopril improve blood pressure control in patients with severe refractory hypertension?
Combining minoxidil and captopril can achieve satisfactory blood pressure control in severe refractory hypertension while allowing for lower minoxidil doses to minimize adverse effects.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for minoxidil-captopril in refractory hypertension; prospective trials needed before clinical adoption.
The BP of four patients with severe hypertension could not be controlled by treatment with a variety of drugs including minoxidil and captopril. Satisfactory responses were obtained only when minoxidil and captopril were given in combination (along with diuretic and beta-adrenergic blocking agents). The doses of minoxidil could be reduced by the addition of captopril and adverse effects were thus minimized. The state of the renin-angiotensin system prior to therapy was not a reliable predictor of the hypotensive response of the combination.
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Yehuda M. Traub (1983) studied this question.
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