Why the study?
Does minoxidil reduce blood pressure and maintain consistent pharmacokinetics in patients with severe hypertension and varying degrees of renal function?
Does minoxidil reduce blood pressure and maintain consistent pharmacokinetics in patients with severe hypertension and varying degrees of renal function?
Minoxidil provides sustained blood pressure reduction in severe hypertension with predictable kinetics regardless of renal impairment, though it requires concomitant therapy for reflex tachycardia and fluid retention.
May support sustained BP reduction with minoxidil in severe hypertension irrespective of renal function; leaves open controlled confirmation of kinetics and outcomes.
Minoxidil was used to treat 26 patients (17 to 67 years old) with severe hypertension and varying degrees of renal function. Our object was to assess long-term clinical efficacy, kinetics (acute and chronic), and bioavailability of minoxidil in chronic renal insufficiency. Minoxidil, 27 to 30 mg per day, decreased systolic and diastolic blood pressure during the first three months of therapy. Between the third and 24th months (30 months in one patient) there was no further change. Propranolol or clonidine was needed to control heart rate, and furosemide or dialysis was needed to control edema induced by minoxidil. Renal function improved in some of the mildy azotemic patients. Minoxidil kinetics after the customary dose did not differ whether the drug was taken as tablet or solution. Kinetic parameters during chronic administration of minoxidil did not differ from those after acute administration. The kinetics in chronic renal insufficiency do not differ from these in subjects with normal renal function.
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Löwenthal et al. (1978) studied this question.
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