May 1, 1979Archives of Internal Medicine
Rapid blood pressure control with minoxidil: acute and chronic effects on blood pressure, sodium excretion, and the renin-aldosterone system
Why the study?
Does minoxidil reduce blood pressure in severely hypertensive patients treated with a diuretic and propranolol?
Population
12 severely hypertensive patients
Comparison
Minoxidil added to a regimen of a diuretic and… vs Pretreatment baseline
Design
Case_series
Follow-up
2 months (for a subset of 6 subjects)
Authors
Discussion
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Implication
Minoxidil may aid BP control in refractory hypertension on diuretic plus propranolol; case report leaves open confirmation of transient effects in controlled trials.
Structured PICO
Does minoxidil reduce blood pressure in severely hypertensive patients treated with a diuretic and propranolol?
P
Population
12 severely hypertensive patients
I
Intervention
Minoxidil (up to 40 mg daily) added to a regimen of a diuretic and propranolol hydrochloride
C
Comparator
Pretreatment baseline (patients on diuretic and propranolol hydrochloride)
O
Outcome
Changes in blood pressure, heart rate, electrolyte excretion, and the renin-angiotensin-aldosterone systemsurrogate
Minoxidil is an effective add-on therapy for severe hypertension, causing transient acute sodium retention and renin elevation that resolve with chronic use.
Cite This Study
Clarence E. Grim (1979) studied this question.