Why the study?
Does aggressive dosing of oral minoxidil expeditiously reduce blood pressure in patients with severe essential hypertension?
Population
12 patients with essential hypertension and pretreatment blood pressure ranging from 159/109 to 238/161 mm Hg
Design
Case_series
Follow-up
24 to 42 hours
Authors
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May enable rapid oral minoxidil titration for severe hypertension without hypotension; hypothesis-generating case series leaves open need for controlled trials.
Does aggressive dosing of oral minoxidil expeditiously reduce blood pressure in patients with severe essential hypertension?
An aggressive oral minoxidil regimen safely and effectively controls severe essential hypertension within 24 to 42 hours, providing an alternative to parenteral therapy when immediate control is not required.
O'Malley et al. (1975) studied this question.
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