Key result
The hypotensive effect of minoxidil declined linearly with time (average biologic half-life of about 1 day), with the rate of decline dependent on baseline mean arterial pressure rather than dose.
Why the study?
Does minoxidil reduce blood pressure in patients with varying degrees of hypertension?
Population
6 patients with varying degrees of hypertension (baseline mean arterial pressure 122 to 197 mm Hg)
Design
Case_series
Authors
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Minoxidil response duration may vary with baseline MAP; leaves open individualized dosing pending prospective validation.
Does minoxidil reduce blood pressure in patients with varying degrees of hypertension?
Minoxidil dosage regimens, specifically loading dose and dosing frequency, should be individualized based on the severity of baseline hypertension.
Shen et al. (1975) studied Hypertension (n=6). Minoxidil was evaluated on Temporal pattern of hypotensive effect. The hypotensive effect of minoxidil declined linearly with time (average biologic half-life of about 1 day), with the rate of decline dependent on baseline mean arterial pressure rather than dose.
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