Key result
Single oral doses of 2.5 to 10.0 mg of minoxidil demonstrated dose-independent pharmacokinetics and had little clinically significant effect on blood pressure in normotensive subjects.
Why the study?
Does minoxidil exhibit dose-proportional pharmacokinetics across 2.5 to 10 mg oral doses in healthy volunteers?
Population
30 young, nonobese, normal subjects
Comparison
Single oral doses of minoxidil 2.5, 5.0, and… vs Intra-individual comparison across different doses
Design
Other, Latin square cross-over design
Follow-up
4-day washout period between treatments
Authors
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Supports dose-independent PK with minimal BP effects for low-dose oral minoxidil in healthy subjects; leaves open translation to patients.
RCT (n=30)
Latin square cross-over
Does minoxidil exhibit dose-proportional pharmacokinetics across 2.5 to 10 mg oral doses in healthy volunteers?
Minoxidil exhibits dose-independent pharmacokinetics between 2.5 and 10 mg oral doses and has minimal effect on blood pressure in healthy normotensive individuals.
Fleishaker et al. (1989) conducted an RCT in Healthy volunteers (n=30). Minoxidil vs. Different doses of minoxidil (cross-over) was evaluated on Dose proportionality (pharmacokinetics). Single oral doses of 2.5 to 10.0 mg of minoxidil demonstrated dose-independent pharmacokinetics and had little clinically significant effect on blood pressure in normotensive subjects.
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