Population
Smooth muscle isolated from guinea-pig stomach
Comparison
Metabolic inhibition using cyanide 1 mM and… vs Control (baseline or untreated state)
Design
Preclinical
Follow-up
Up to 50 minutes of application
Authors
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Metabolic inhibition may suppress gastric motility to conserve energy in ischemia; leaves open relevance to human smooth muscle disorders.
In guinea-pig stomach smooth muscle, metabolic inhibition reduces or eliminates spontaneous activity to preserve high-energy phosphates and cell viability, via a mechanism independent of ATP-sensitive K+ channels.
Nakayama et al. (1997) studied this question.
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