May 1, 1983AJP Cell Physiology

Excitation-contraction coupling without Ca2+ action potentials in small intestine

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Population

Small intestine tissue (preclinical model)

Design

Preclinical

Authors

KSKerrie M. SandersThe University of Melbourne

Discussion

Member takes

Implication

Highlights Ca2+-dependent intestinal contraction via slow waves; hypothesis-generating for motility research, should not yet change practice.

Structured PICO

Population

Small intestine tissue (preclinical model)

Intervention

Acetylcholine (10(-8) to 10(-6) M) and Mn2+ (0.5 mM)

Outcome

Relationship between slow-wave amplitude and amplitude of phasic contractionssurrogate

The study demonstrates that an increase in intracellular Ca2+ during slow waves is sufficient to activate the contractile apparatus in the small intestine, even without Ca2+ action potentials.

Cite This Study

Kerrie M. Sanders (1983) studied this question.

synapsesocial.com/papers/6a83874ad71a93cd45e4e5e4 https://doi.org/10.1152/ajpcell.1983.244.5.c356

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Implication

Highlights Ca2+-dependent intestinal contraction via slow waves; hypothesis-generating for motility research, should not yet change practice.

Excitation-contraction coupling without Ca2+ action potentials in small intestine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Excitation-contraction coupling without Ca2+ action potentials in small intestine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider