January 1, 1986The Japanese Journal of PhysiologyOpen Access

Effect of calcium antagonists on vascular responses of bovine coronary artery to acetylcholine, noradrenaline, and 5-hydroxytryptamine.

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Population

Bovine coronary artery model

Design

Preclinical

Authors

FWF. A. WALI EGE. GREENIDGE

Discussion

Member takes

Implication

Bovine artery data should not alter clinical CCB use; leaves open human coronary translation.

Structured PICO

Population

Bovine coronary artery model

Intervention

Calcium antagonists (verapamil 0.05-5 microM, diltiazem 0.2-20 microM, and nifedipine 0.3-30 microM)

Outcome

Vascular relaxation and modification of contractile responses to acetylcholine, noradrenaline, and 5-hydroxytryptaminesurrogate

Verapamil is more potent than diltiazem and nifedipine in relaxing bovine coronary arteries and modulates vascular responses to key neurotransmitters.

Cite This Study

WALI et al. (1986) studied this question.

synapsesocial.com/papers/6a8387c7b397c5df40cd7d95 https://doi.org/10.2170/jjphysiol.36.807

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Effect of calcium antagonists on vascular responses of bovine coronary artery to acetylcholine, noradrenaline, and 5-hydroxytryptamine.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of calcium antagonists on vascular responses of bovine coronary artery to acetylcholine, noradrenaline, and 5-hydroxytryptamine.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider