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January 1, 2010American Journal of Nephrology

Effects of Interleukin-6 on Depression Risk in Dialysis Patients

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Population

44 stable patients with end-stage kidney disease and 20 healthy age- and gender-matched controls.

Design

Case-control

Authors

MSMakrouhi SonikianSismanoglio General HospitalPMPolyxeni MetaxakiSimanogleio-Amalia Fleming General HospitalDPDimitrios PapavasileiouNational and Kapodistrian University of Athens

Discussion

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Implication

May link inflammation to depression in ESKD; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
44 stable patients with end-stage kidney disease (ESKD) (mean age 64 +/- 13 years, 32 males, 27 on hemodialysis, 17 on peritoneal dialysis) and 20 healthy age- and gender-matched controls (mean age 60 +/- 12 years, 12 males).
C
Comparator
Healthy age- and gender-matched individuals
O
Outcome
Relationship between depression (assessed by Zung Self-Rating Depression Scale) and cytokines (IL-6, TNF-alpha, and IL-10)surrogate

Elevated IL-6 levels are correlated with higher depression scores in patients with end-stage kidney disease, suggesting a potential role of inflammation in the pathogenesis of depression in this population.

Limitations

  • Pilot study (small sample size)

Cite This Study

Sonikian et al. (2010) studied this question.

synapsesocial.com/papers/6a83a6f38dcee831255bcaebhttps://doi.org/10.1159/000285110
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  4. 4Common Genetic Contributions to Depressive Symptoms and Inflammatory Markers in Middle-Aged Men: The Twins Heart Study2008 · 87 citations
  5. 5Depression and C-Reactive Protein in US Adults2004 · 549 citations