Why the study?
Do restriction fragment length polymorphisms at the locus for atrial natriuretic factor affect blood pressure level or variability in healthy Norwegians?
Do restriction fragment length polymorphisms at the locus for atrial natriuretic factor affect blood pressure level or variability in healthy Norwegians?
Polymorphisms at the ANF locus do not appear to influence normal blood pressure levels or variability in healthy individuals.
No link between ANF polymorphisms and BP level or variability in healthy Norwegians; leaves open effects in hypertension or other populations.
We have examined healthy Norwegians with respect to two restriction fragment length polymorphisms at the locus for atrial natriuretic factor, detectable with the restriction enzymes XhoI and BglI, respectively. No association with systolic or diastolic blood pressure level or variability was found. Thus, the normal genes detected by examination of these restriction fragment length polymorphisms have neither "level gene" nor "variability gene" effects on normal blood pressure.
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Berge et al. (1994) studied this question.
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