Why the study?
Does a BglI polymorphism at the renin locus affect blood pressure level or variability in healthy Norwegians?
Does a BglI polymorphism at the renin locus affect blood pressure level or variability in healthy Norwegians?
A BglI polymorphism at the renin locus does not appear to influence blood pressure levels or variability in healthy individuals.
No BP link from renin BglI variant in healthy Norwegians; leaves open effects in hypertension or other populations.
We have studied a normal restriction fragment length polymorphism at the renin locus, detected with the restriction enzyme BglI in healthy Norwegians. No association with blood pressure level or variability was found. Thus, the normal genes detected by examination of this restriction fragment length polymorphism at the renin locus have neither "level gene" nor "variability gene" effects on normal blood pressure.
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Berge et al. (1994) studied this question.
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