Population
Intact Wistar-Kyoto rat, WKY with stimulated renin-angiotensin system, human cadaver kidney, and hog kidney
Design
Preclinical
Authors
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Species differences in renin forms caution against direct animal-to-human extrapolation; extends biochemical mapping but leaves open clinical relevance.
The study demonstrates that high molecular weight renin in hog kidneys can be converted to low molecular weight renin via mechanisms involving disulfide bonds rather than a sulfhydryl-requiring enzyme.
Morimoto et al. (1980) studied this question.
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