Why the study?
Does pretreatment with kallikrein, plasmin, or thrombin alter the activity or molecular weight of hog high molecular weight renin?
Population
Hog high molecular weight renin (in vitro model)
Comparison
Pretreatment with kallikrein, thrombin, or… vs Untreated renin or comparison between different…
Design
Preclinical
Authors
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Activates high-MW hog renin without cleavage in this model; hypothesis-generating for protease regulation of the renin-angiotensin system in humans.
Does pretreatment with kallikrein, plasmin, or thrombin alter the activity or molecular weight of hog high molecular weight renin?
Thrombin and kallikrein activate hog high molecular weight renin without converting it to a lower molecular weight form (Mr = 43,000).
Overturf et al. (1979) studied this question.
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