Why the study?
Does antithrombin III reduce leukocyte and platelet recruitment and retinal damage in a rat model of retinal ischemia-reperfusion injury?
Population
Male Long-Evans rats with transient retinal ischemia induced for 60 minutes by ligation of the optic nerve
Comparison
Antithrombin-III administered intravenously just… vs Control
Design
Preclinical
Follow-up
14 days
Authors
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May support antithrombin III for retinal neuroprotection; hypothesis-generating in this animal model and leaves open human translation.
Does antithrombin III reduce leukocyte and platelet recruitment and retinal damage in a rat model of retinal ischemia-reperfusion injury?
Antithrombin III inhibits leukocyte and platelet recruitment to the postischemic retina, providing neuroprotection against ischemia-reperfusion injury in a rat model.
Nishijima et al. (2003) studied this question.
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