Population
Hearts from 2 day-old rats (n=14)
Comparison
Perfusion with a LacZ-encoding adenovirus at 3 x… vs Uninfected controls (n=7)
Design
Preclinical
Follow-up
24 hours
Authors
Loading...
Supports ex vivo adenoviral gene transfer models; leaves open in vivo applicability and clinical translation.
The 24-h Langendorff-perfused neonatal rat heart is a feasible and robust ex vivo model for functional genomics and efficient adenoviral gene transfer.
Wiechert et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: