September 16, 2003Cardiovascular ResearchOpen Access

Sp1 and Sp3 transcription factors are required for trans-activation of the human SERCA2 promoter in cardiomyocytes

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Population

Primary cultures of neonatal rat ventricular myocytes

Design

Preclinical

Authors

MBMariea A. BradyOxford University Hospitals NHS Trust

Discussion

Member takes

Implication

Sp1/Sp3 may regulate SERCA2 in animal cardiomyocytes; hypothesis-generating, leaves open human disease relevance and should not change practice.

Structured PICO

Population

Primary cultures of neonatal rat ventricular myocytes

Intervention

Transient transfection with luciferase reporter gene constructs containing deletions of the SERCA2 promoter or mutations in consensus Sp1 transcription factor binding sites

Outcome

SERCA2 promoter activitysurrogate

Sp1 and Sp3 transcription factors are essential for the transactivation of the human SERCA2 gene in cardiomyocytes.

Cite This Study

Mariea A. Brady (2003) studied this question.

synapsesocial.com/papers/6a83de5154d5d3123e3c2ef2 https://doi.org/10.1016/s0008-6363(03)00529-7

View Full Paper

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Implication

Sp1/Sp3 may regulate SERCA2 in animal cardiomyocytes; hypothesis-generating, leaves open human disease relevance and should not change practice.

Sp1 and Sp3 transcription factors are required for trans-activation of the human SERCA2 promoter in cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sp1 and Sp3 transcription factors are required for trans-activation of the human SERCA2 promoter in cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider