April 15, 1997Proceedings of the National Academy of SciencesOpen Access

P 1 , P 4 -Dithio- P 2 , P 3 -monochloromethylene diadenosine 5′,5‴- P 1 , P 4 -tetraphosphate: A novel antiplatelet agent

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Why the study?

Does Ap(s)pCHClpp(s)A inhibit platelet aggregation in vitro compared to AppCHClppA?

Population

In vitro platelet models

Comparison

AppCHClppA vs AppCHClppA

Design

Preclinical

Authors

SCSamuel W. ChanFoundation for Biomedical Research SGSteven J. GalloUniversity of Sheffield BKByung K. KimFoundation for Biomedical Research

Discussion

Member takes

Implication

Supports preclinical development of stable antiplatelet dinucleotides; leaves open in vivo efficacy and safety.

Structured PICO

Does Ap(s)pCHClpp(s)A inhibit platelet aggregation in vitro compared to AppCHClppA?

Population

In vitro platelet models

Intervention

Ap(s)pCHClpp(s)A (a newly synthesized diadenosine polyphosphate analogue)

Comparator

AppCHClppA

Outcome

Inhibitory effects on ADP-induced platelet aggregationsurrogate

Ap(s)pCHClpp(s)A is a novel, stable antiplatelet agent that effectively inhibits platelet aggregation induced by multiple agonists in vitro.

Cite This Study

Chan et al. (1997) studied this question.

synapsesocial.com/papers/6a83ef2720cfb2932ffe2b01 https://doi.org/10.1073/pnas.94.8.4034

Topics

Dual antiplatelet therapy

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P 1 , P 4 -Dithio- P 2 , P 3 -monochloromethylene diadenosine 5′,5‴- P 1 , P 4 -tetraphosphate: A novel antiplatelet agent

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

P 1 , P 4 -Dithio- P 2 , P 3 -monochloromethylene diadenosine 5′,5‴- P 1 , P 4 -tetraphosphate: A novel antiplatelet agent

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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