January 1, 2008Hämostaseologie

Thrombelastography is not suitable to detect von Willebrand disease

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Why the study?

Does native thrombelastography accurately detect unknown von Willebrand disease in children?

Structured PICO

Does native thrombelastography accurately detect unknown von Willebrand disease in children?

Population

Children undergoing coagulation screening, including 28 patients with von Willebrand disease (VWD) type 1 (39 samples), 21 patients with VWD type 2a (30 samples), and a control group of children from the coagulation ward where VWD was excluded (225 samples).

Intervention

Native thrombelastography

Comparator

Control group of children without VWD

Outcome

Sensitivity and specificity for diagnosing VWD (measured via clotting time, clot formation time, and clot firmness)surrogate

Native thrombelastography is not a sensitive or specific screening tool for detecting unknown von Willebrand disease in children.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Native thrombelastography should not screen for unknown von Willebrand disease in children; leaves open whether modified or alternative viscoelastic assays perform better.

Cite This Study

Schwarte et al. (2008) studied this question.

synapsesocial.com/papers/6a83fac7d65172829ee670ca https://doi.org/10.1055/s-0037-1621624

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Implication

Native thrombelastography should not screen for unknown von Willebrand disease in children; leaves open whether modified or alternative viscoelastic assays perform better.

Thrombelastography is not suitable to detect von Willebrand disease

Structured PICO

Discussion

Implication

Cite This Study

Thrombelastography is not suitable to detect von Willebrand disease

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider