Why the study?
Do beta-adrenoceptor antagonists with intrinsic sympathomimetic activity induce vascular relaxation in human arteries and veins?
Population
33 preparations of human arteries and veins and 10 human umbilical artery preparations contracted by…
Comparison
Beta-adrenoceptor antagonists with intrinsic… vs Pretreatment with propranolol or sotalol
Design
Preclinical
Authors
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Hypothesis-generating for beta2-mediated effects of ISA beta-blockers; leaves open translation to human vessels.
Do beta-adrenoceptor antagonists with intrinsic sympathomimetic activity induce vascular relaxation in human arteries and veins?
Beta-blockers with intrinsic sympathomimetic activity like pindolol and celiprolol produce vascular relaxation via beta 2-adrenoceptor stimulation, which may contribute to their hemodynamic effects in humans.
Thulesius et al. (1982) studied this question.
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