December 1, 1998The Journal of Clinical Endocrinology & MetabolismOpen Access

The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency

View Full Paper

Ask AI

Bookmark

Why the study?

Does determination of circulating Acid-Labile Subunit (ALS) concentrations accurately diagnose growth hormone deficiency?

Structured PICO

Does determination of circulating Acid-Labile Subunit (ALS) concentrations accurately diagnose growth hormone deficiency?

Population

1,304 subjects total, comprising 30 undergoing liver vein catheterization, 8 for diurnal variation assessment, 1,158 healthy subjects for normal age-related ranges, and 108 patients with childhood-onset growth hormone deficiency (GHD).

Intervention

Determination of circulating Acid-Labile Subunit (ALS) concentrations

Comparator

IGF-I and IGFBP-3 determinations (for diagnostic utility comparison)

Outcome

Diagnostic sensitivity and specificity of ALS for growth hormone deficiency, hepatosplanchnic release, diurnal variation, and normal age-related rangessurrogate

Circulating ALS levels exhibit minor diurnal variation and have diagnostic utility similar to IGF-I and IGFBP-3 for classifying patients suspected of growth hormone deficiency.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

ALS offers diagnostic performance similar to IGF-I for GHD; leaves open whether it adds clinical value beyond current markers.

Cite This Study

Juul et al. (1998) studied this question.

synapsesocial.com/papers/6a840f30d87e21f83cb2918e https://doi.org/10.1210/jcem.83.12.5311

View Full Paper

Ask AI

Bookmark

The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency

Structured PICO

Discussion

Implication

Cite This Study

The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider