Key result
Female gender and left atrial enlargement linked to ~100% higher odds of non-PV AF triggers.
Why the study?
Non-pulmonary vein ectopic beats can initiate paroxysmal atrial fibrillation and contribute to recurrence after pulmonary vein isolation, but predictors of these triggers were unknown.
What are the clinical predictors of non-pulmonary vein ectopic beats initiating paroxysmal atrial fibrillation?
Population
293 patients with clinically documented drug-refractory PAF
Comparison
Patients with vs without non-PV ectopic beats initiating PAF
Design
Observational study
Authors
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Gender and LA enlargement may inform non-PV trigger mapping in PAF ablation; leaves open whether targeted ablation improves outcomes.
Observational (n=293)
What are the clinical predictors of non-pulmonary vein ectopic beats initiating paroxysmal atrial fibrillation?
Odds Ratio: 2 (95% CI 1.02–3.92)
p-value: p=0.043
Female gender and left atrial enlargement are significant independent predictors of non-pulmonary vein ectopic beats initiating paroxysmal atrial fibrillation.
Lee et al. (2005) conducted an observational in Paroxysmal atrial fibrillation (n=293). Female gender and left atrial enlargement vs. Male gender and normal left atrial size was evaluated on Presence of non-pulmonary vein ectopic beats (OR 2.00, 95% CI 1.02-3.92, p=0.043). Female gender (OR 2.00; 95% CI 1.02-3.92) and left atrial enlargement (OR 2.34; 95% CI 1.27-4.32) independently predicted the presence of non-pulmonary vein ectopic beats initiating paroxysmal AF.
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