Key result
Etomidate with nalbuphine provided significantly greater hemodynamic stability during induction and intubation compared to propofol with nalbuphine.
Why the study?
Propofol provides rapid anesthesia and recovery, while etomidate is preferred in cardiac patients, prompting a comparison of hemodynamic parameters, onset, efficacy, and adverse effects when combined with nalbuphine.
Does etomidate with nalbuphine improve hemodynamic stability compared to propofol with nalbuphine in patients undergoing major surgeries under general anesthesia?
RCT (n=60)
Computer generated randomization
No
Does etomidate with nalbuphine improve hemodynamic stability compared to propofol with nalbuphine in patients undergoing major surgeries under general anesthesia?
Etomidate combined with nalbuphine provides superior hemodynamic stability during the induction of general anesthesia compared to propofol with nalbuphine.
Supports etomidate-nalbuphine for stable induction in major surgery; extends RCT evidence for alternatives to propofol-nalbuphine.
INTRODUCTION: Propofol provides rapid and smooth anesthesia with quick recovery and less incidence of vomiting. Etomidate is inducing agent of choice in cardiac patients.We are comparing the effects of these drugs when given along with nalbuphine.This study aims to compare the hemodynamic parameters, onset and efficacy of these combinations and adverse effects. MATERIALS AND METHOD:60 patients belonging to ASA I -II of either sex undergoing major surgeries under general anesthesia were included in our study. The study was prospective observational study, 60 patients were randomized equal into two groups to receive either propofol with nalbuphine or etomidate with nalbuphine. RESULT:Etomidate group showed more hemodynamic stability compared to Propofol group
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Aju Joy (2019) conducted an RCT in Major surgeries under general anesthesia (n=60). Etomidate with nalbuphine vs. Propofol 1.5 mg/kg IV + nalbuphine 0.1 mg/kg IV was evaluated on Hemodynamic stability (heart rate and mean blood pressure) during induction and intubation. Etomidate with nalbuphine provided significantly greater hemodynamic stability during induction and intubation compared to propofol with nalbuphine.
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