Key result
Intravenous lovastatin acutely reduced platelet deposition in a porcine carotid injury model compared to saline control (944 vs 3149 x 10^6/cm^2; P=0.02).
Why the study?
Does intravenous lovastatin reduce platelet thrombus formation in a porcine carotid injury model?
Population
Porcine carotid injury model (n=17 pigs)
Comparison
Intravenous lovastatin vs Intravenous saline
Design
Preclinical
Follow-up
30 minutes
Authors
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Suggests pleiotropic antiplatelet effects of statins; hypothesis-generating and leaves open human clinical relevance.
Does intravenous lovastatin reduce platelet thrombus formation in a porcine carotid injury model?
Absolute Event Rate: 944% vs 3149%
p-value: p=0.02
Intravenous lovastatin acutely attenuates arterial thrombus formation in a porcine injury model, suggesting a pleiotropic antiplatelet effect of statins.
Obi et al. (2009) studied Arterial thrombosis (n=17). Intravenous lovastatin vs. Saline was evaluated on Thrombus size (platelet deposition) in the second injured artery (p=0.02). Intravenous lovastatin acutely reduced platelet deposition in a porcine carotid injury model compared to saline control (944 vs 3149 x 10^6/cm^2; P=0.02).
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