Why the study?
Does inhibition of Ang1 expression by antisense RNA reduce tumor growth and angiogenesis in immunodeficient mice with HeLa cell xenografts?
Population
HeLa cells and immunodeficient mice with xenograft tumors
Comparison
Inhibition of Angiopoietin-1 expression by an… vs Control tumors
Design
Preclinical
Authors
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Ang1 inhibition merits further preclinical testing as an anti-angiogenic strategy; leaves open translation to clinical oncology.
Does inhibition of Ang1 expression by antisense RNA reduce tumor growth and angiogenesis in immunodeficient mice with HeLa cell xenografts?
Inhibition of Ang1 expression via antisense RNA effectively controls tumor growth by inhibiting tumor angiogenesis in a preclinical xenograft model.
Shim et al. (2001) studied this question.
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