Key result
Intravenous infusion of a very small dose of hypertonic saline in anesthetized rats produced transient hypotension, suggesting a sympathosympathetic neural reflex mechanism.
Why the study?
Does intravenous infusion of hypertonic saline induce transient hypotension via a neural reflex in anesthetized rats?
Does intravenous infusion of hypertonic saline induce transient hypotension via a neural reflex in anesthetized rats?
The transient hypotension induced by small doses of intravenous hypertonic saline in rats appears to be mediated by a sympathosympathetic neural reflex involving cardiopulmonary afferents and vasomotor efferents.
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May induce reflex hypotension in anesthetized models; leaves open translation to clinical hypertonic saline use or human reflex physiology.
Dongmei Zhang (2009) studied Anesthetized rats. Intravenous infusion of hypertonic saline (0.97-9.7% NaCl) was evaluated on Transient hypotension (depressor response). Intravenous infusion of a very small dose of hypertonic saline in anesthetized rats produced transient hypotension, suggesting a sympathosympathetic neural reflex mechanism.
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