Why the study?
Does pregnancy alter the mechanisms of endothelium-dependent relaxation in human omental microvessels?
Population
Human omental resistance vessels dissected from omental biopsies obtained from women at laparotomy or at…
Comparison
Acetylcholine and bradykinin-induced relaxation… vs Vessels from nonpregnant women compared to…
Design
Preclinical
Authors
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Supports pregnancy-augmented inhibitor-insensitive relaxation in human omental vessels; leaves open pathway identification and clinical relevance.
Does pregnancy alter the mechanisms of endothelium-dependent relaxation in human omental microvessels?
Human pregnancy augments an endothelium-dependent relaxation mechanism in omental microvessels that is insensitive to standard nitric oxide, prostanoid, and potassium channel inhibitors.
Pascoal et al. (1996) studied this question.
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