Key result
In individuals with normal glucose tolerance, circulating betatrophin levels were independently and positively associated with the visceral-to-subcutaneous adipose tissue ratio (standardized β = 0.419, p = 0.001).
Why the study?
Because BMI reflects overall adiposity rather than fat distribution, it remained unclear whether fat deposition in different body areas affects betatrophin expression across different glucose tolerance states.
Population
128 participants with impaired glucose tolerance (n = 64) or normal glucose tolerance (n = 64)
Comparison
Impaired glucose tolerance vs normal glucose tolerance
Design
Cross-sectional study
Authors
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May mark visceral adiposity in normoglycemia; hypothesis-generating and requires prospective validation before any clinical use.
Cross-Sectional (n=128)
Yes
Effect estimate: standardized β = 0.419
p-value: p=0.001
Circulating betatrophin levels correlate positively with the visceral-to-subcutaneous fat ratio in individuals with normal glucose tolerance, suggesting it may serve as a biomarker for body fat distribution.
Zheng et al. (2020) conducted a cross-sectional in Impaired or Normal Glucose Tolerance (n=128). Circulating betatrophin levels was evaluated on Independent association between serum betatrophin levels and visceral adipose tissue-to-subcutaneous adipose tissue (VAT/SAT) ratio in the NGT group (standardized β = 0.419, p=0.001). In individuals with normal glucose tolerance, circulating betatrophin levels were independently and positively associated with the visceral-to-subcutaneous adipose tissue ratio (standardized β = 0.419, p = 0.001).
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