Key result
Higher serum betatrophin levels were significantly associated with an increased risk of diabetic nephropathy in patients with type 2 diabetes (OR 5.65).
Why the study?
Is serum betatrophin level associated with urinary albumin excretion and renal function in patients with type 2 diabetes mellitus?
Population
141 Taiwanese subjects, including 32 healthy subjects and 109 patients with type 2 diabetes mellitus. The…
Design
Cross-sectional
Authors
Loading...
May support betatrophin as nephropathy biomarker in type 2 diabetes; hypothesis-generating, requiring prospective validation before clinical use.
Cross-Sectional (n=141)
No
Is serum betatrophin level associated with urinary albumin excretion and renal function in patients with type 2 diabetes mellitus?
Odds Ratio: 5.65 (95% CI 2.17–14.57)
p-value: p=<0.001
Serum betatrophin levels are significantly elevated in type 2 diabetes patients with albuminuria and independently correlate with the presence of diabetic nephropathy, suggesting a potential role as a biomarker for renal complications.
Chen et al. (2016) conducted a cross-sectional in Type 2 diabetes mellitus and diabetic nephropathy (n=141). Serum betatrophin level vs. Healthy subjects was evaluated on Diabetic nephropathy (ACR > 300 mg/g) (OR 5.65, 95% CI 2.17-14.57, p=<0.001). Higher serum betatrophin levels were significantly associated with an increased risk of diabetic nephropathy in patients with type 2 diabetes (OR 5.65).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: