Key result
Higher serum betatrophin concentration was significantly associated with an increased risk of diabetic retinopathy in treated type 2 diabetes patients (OR 2.01; 95% CI 1.12-3.60; p=0.019).
Population
140 subjects including gender-, age-, and BMI-matched T2DM patients with or without diabetic retinopathy…
Design
Case-control
Authors
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Association does not support betatrophin testing for retinopathy risk in T2DM; leaves open its value as biomarker pending prospective studies.
Case-Control (n=140)
Odds Ratio: 2.01 (95% CI 1.12–3.6)
p-value: p=0.019
Serum betatrophin concentrations are elevated in treated T2DM patients and positively associated with the presence of diabetic retinopathy.
Wang et al. (2016) conducted a case-control in Type 2 diabetes and diabetic retinopathy (n=140). Serum betatrophin concentration vs. Lower betatrophin concentration / Healthy subjects was evaluated on Diabetic retinopathy (OR 2.01, 95% CI 1.12-3.60, p=0.019). Higher serum betatrophin concentration was significantly associated with an increased risk of diabetic retinopathy in treated type 2 diabetes patients (OR 2.01; 95% CI 1.12-3.60; p=0.019).
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