February 1, 2001The Journal of PhysiologyOpen Access

G protein‐mediated inhibitory effect of a nitric oxide donor on the L‐type Ca2+ current in rat ventricular myocytes

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Population

Rat ventricular myocytes

Comparison

Nitric oxide donors vs Basal conditions, other NO donors, or presence…

Design

Preclinical

Authors

NANajah Abi‐GergesAnaBios (United States)RFRodolphe FischmeisterElectrophysiology PMPierre‐François MéryCentre National de la Recherche Scientifique

Discussion

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Implication

Hypothesis-generating for NO-cGMP anti-adrenergic signaling in myocytes; leaves open relevance to human HF or arrhythmias.

Structured PICO

Population

Rat ventricular myocytes

Intervention

Nitric oxide donors (specifically DEANO 10-100 microM)

Comparator

Basal conditions, other NO donors, or presence of pathway inhibitors (ODQ, cG-PK inhibitors, pertussis toxin)

Outcome

Modulation of the cardiac L-type Ca2+ current (ICa,L)surrogate

The NO donor DEANO exerts an anti-adrenergic inhibitory effect on L-type Ca2+ currents in rat ventricular myocytes via a cGMP-dependent pathway and a pertussis toxin-sensitive G protein.

Cite This Study

Abi‐Gerges et al. (2001) studied this question.

synapsesocial.com/papers/6a843caff6d812dcfa83d99e https://doi.org/10.1111/j.1469-7793.2001.0117j.x

View Full Paper

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Bookmark

G protein‐mediated inhibitory effect of a nitric oxide donor on the L‐type Ca2+ current in rat ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

G protein‐mediated inhibitory effect of a nitric oxide donor on the L‐type Ca2+ current in rat ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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