September 1, 1998The Journal of PhysiologyOpen Access

Cyclic GMP‐dependent but G‐kinase‐independent inhibition of Ca2+‐dependent Cl− currents by NO donors in cat tracheal smooth muscle

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Population

Freshly isolated cat tracheal myocytes

Comparison

Nitric oxide donors vs Control conditions (absence of NO donors)

Design

Preclinical

Authors

YWYoshiki WaniishiKyushu University RIRyuji InoueElectrophysiology HMHiromitsu MoritaFukuoka Dental College

Discussion

Member takes

Implication

Does not support clinical use in airway disease; leaves open mechanistic role of cGMP in human smooth muscle Cl- currents.

Structured PICO

Population

Freshly isolated cat tracheal myocytes

Intervention

Nitric oxide (NO) donors (S-nitroso-N-acetyl penicillamine [SNAP], glyceryl trinitrate [GTN], NO-R)

Comparator

Control conditions (absence of NO donors)

Outcome

Amplitude of Ca2+-dependent Cl- currents (ICCh)surrogate

NO donors inhibit Ca2+-dependent Cl- currents in cat tracheal smooth muscle via a cGMP-dependent but G-kinase-independent mechanism operating between muscarinic and IP3 receptors.

Cite This Study

Waniishi et al. (1998) studied this question.

synapsesocial.com/papers/6a91086556ba240a28cae1f2 https://doi.org/10.1111/j.1469-7793.1998.719bg.x

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Cyclic GMP‐dependent but G‐kinase‐independent inhibition of Ca2+‐dependent Cl− currents by NO donors in cat tracheal smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cyclic GMP‐dependent but G‐kinase‐independent inhibition of Ca2+‐dependent Cl− currents by NO donors in cat tracheal smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider