May 1, 1990Journal of Pharmacy and Pharmacology

Effects of Verapamil, Nifedipine and Flunarizine on Haemodynamics and Regional Blood Flows in Pentobarbitone-anaesthetized Rats

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Population

pentobarbitone-anaesthetized rats

Design

Preclinical

Authors

RWR WaiteSanden (Japan)CPCatherine C.Y. PangQueen Elizabeth Hospital Birmingham MWMichael WalkerIsrael Institute for Biological Research

Discussion

Member takes

Implication

Distinct rat-model effects on heart rate and conduction are hypothesis-generating; clinical translation requires prospective human studies.

Structured PICO

Population

pentobarbitone-anaesthetized rats

Intervention

Verapamil, nifedipine, and flunarizine at low and high infusion rates (chosen to decrease mean arterial pressure by 25 and 40 mmHg, respectively)

Outcome

Effects on blood pressure, heart rate, ventricular pressures, ECG, cardiac output and regional blood flowsurrogate

Representatives from three sub-classes of calcium antagonists demonstrate similar vasodilatory effects on regional blood flow but exert distinct electrophysiological and chronotropic effects on the heart in a rat model.

Cite This Study

Waite et al. (1990) studied this question.

synapsesocial.com/papers/6a843fa43dbf2f1b7f68bffc https://doi.org/10.1111/j.2042-7158.1990.tb05420.x

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Implication

Distinct rat-model effects on heart rate and conduction are hypothesis-generating; clinical translation requires prospective human studies.

Effects of Verapamil, Nifedipine and Flunarizine on Haemodynamics and Regional Blood Flows in Pentobarbitone-anaesthetized Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Verapamil, Nifedipine and Flunarizine on Haemodynamics and Regional Blood Flows in Pentobarbitone-anaesthetized Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider