Why the study?
Do calcium channel antagonists alter cardiac vagal tone at rest and during exercise in mongrel dogs?
Do calcium channel antagonists alter cardiac vagal tone at rest and during exercise in mongrel dogs?
Calcium antagonists can elicit pronounced reductions in cardiac vagal tone in dogs, likely due to baroreceptor reflex activation from hemodynamic changes.
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Should not change human practice; leaves open whether calcium antagonists reduce vagal tone during exercise in patients.
Billman et al. (1992) studied this question.
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