February 1, 1989Circulation ResearchOpen Access

Effects of calcium channel antagonists on carotid sinus baroreflex control of arterial pressure and heart rate in anesthetized dogs.

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Population

Pentobarbital-anesthetized, vagotomized dogs surgically prepared for reversible vascular isolation of the…

Comparison

Intravenous infusion of verapamil, diltiazem… vs Control conditions (prior to infusion).

Design

Preclinical

Follow-up

20 minutes per infusion rate

Authors

DRDean F. RigelNovartis (United States)RMR. W. MillardFlorida Atlantic University

Discussion

Member takes

Implication

May confound baroreflex MAP assessments in vasodilator-treated models; leaves open human translation and mechanism specificity.

Structured PICO

Population

Pentobarbital-anesthetized, vagotomized dogs surgically prepared for reversible vascular isolation of the carotid sinus regions.

Intervention

Intravenous infusion of verapamil (1-30 micrograms/kg/min), diltiazem (1-30 micrograms/kg/min), nifedipine (0.1-3 micrograms/kg/min), or sodium nitroprusside (0.3-10 micrograms/kg/min) for 20 minutes at four rates.

Comparator

Control conditions (prior to infusion).

Outcome

Carotid sinus baroreflex control of mean arterial pressure (MAP) and heart rate (HR), including open-loop CSP-MAP and CSP-HR relations and peak gains.surrogate

Calcium channel antagonists impair carotid sinus baroreflex control of mean arterial pressure but not heart rate, likely due to nonspecific blunting of adrenergic vasoconstriction rather than direct neural effects.

Cite This Study

Rigel et al. (1989) studied this question.

synapsesocial.com/papers/6a7209c65d37378ac1defa45 https://doi.org/10.1161/01.res.64.2.276

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