Why the study?
Do intravenous calcium antagonists alter systemic capacitance vessels and venous return in anesthetized dogs?
Population
Anesthetized, open-chest dogs
Comparison
Intravenous administration of Ca++-antagonists… vs Baseline measurements before administration
Design
Preclinical
Authors
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These canine results should not change practice; leaves open translation of calcium antagonist effects on venous return to humans.
Do intravenous calcium antagonists alter systemic capacitance vessels and venous return in anesthetized dogs?
Calcium antagonists decrease resistance to venous return and increase venous return in dogs, with varying effects on systemic capacitance vessels depending on the specific agent and sympathetic tone.
Kotoo et al. (1988) studied this question.
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