Why the study?
Do calcium antagonists nifedipine and verapamil alter the sensitivity of carotid sinus baroreceptors in dogs?
Do calcium antagonists nifedipine and verapamil alter the sensitivity of carotid sinus baroreceptors in dogs?
Nifedipine and verapamil have opposing effects on carotid sinus baroreceptor sensitivity in dogs, with nifedipine increasing and verapamil decreasing sensitivity, likely due to different ionic mechanisms.
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No immediate clinical implications from canine data; leaves open differential baroreflex effects of calcium antagonist subtypes in humans.
Heesch et al. (1983) studied this question.
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