Key result
KvLQT1 isoform 2 expression was higher in midmyocardial tissue (31.7%) than endocardial (25.2%) and epicardial (24.9%) tissues, which reduced K(+) current amplitude by approximately 75% in vitro.
Population
Human ventricular tissue samples and COS-7 cells
Comparison
Intranuclear injection of KvLQT1 isoforms 1 or 2… vs Different isoform 2-to-isoform 1 ratios…
Design
Preclinical
Authors
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Caution against clinical extrapolation; hypothesis-generating for transmural I(Ks) heterogeneity in ventricular models.
Differential expression of KvLQT1 isoform 2 across the ventricular wall contributes to regional action potential heterogeneity by modulating I(Ks) amplitude.
Péréon et al. (2000) studied this question. KvLQT1 isoform 2-to-isoform 1 ratio vs. Epicardial ratio was evaluated on Relative expression of KvLQT1 isoforms 1 and 2 and K(+) current amplitude. KvLQT1 isoform 2 expression was higher in midmyocardial tissue (31.7%) than endocardial (25.2%) and epicardial (24.9%) tissues, which reduced K(+) current amplitude by approximately 75% in vitro.
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