Why the study?
Current methods for diagnosing lymphocytic myocarditis on endomyocardial biopsy lead to inconsistent diagnoses, prompting a revision of criteria to address shortcomings of the Dallas and ESC criteria.
Design
Expert consensus document
Authors
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Adopts Seaport criteria to standardize lymphocytic myocarditis diagnosis on EMB; extends prior approaches with CD3 IHC grading and SITUS category.
The "Seaport" criteria provide a standardized, consensus-based histopathologic framework using CD3 immunohistochemistry to improve the diagnosis and classification of lymphocytic myocarditis on endomyocardial biopsy.
Halushka et al. (2025) conducted a review in Lymphocytic myocarditis. Seaport criteria was evaluated on Standardized framework for diagnosing lymphocytic myocarditis. The Seaport criteria provide a standardized framework utilizing CD3 immunohistochemistry to classify lymphocytic myocarditis severity into 3 grades (mild, moderate, severe) and SITUS.
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