Key result
Expression of the CSFV NS3 protein in PK-15 cells induced a significantly higher apoptosis rate compared to control cells (43.4% vs 13.1%, p < 0.05).
Population
PK-15 cells
Comparison
Transfection with pEGFP-C1-NS3 vs Transfection with pEGFP-C1 (empty vector)
Design
Preclinical
Follow-up
72 hours
Authors
Loading...
NS3 may drive apoptosis in swine cells; hypothesis-generating for CSFV pathogenesis and requires in vivo validation.
Absolute Event Rate: 43.4% vs 13.1%
p-value: p=< 0.05
Expression of classical swine fever virus NS3 protein induces apoptosis in PK-15 cells, suggesting a mechanism for its cytopathic effect.
Xu et al. (2007) studied Classical swine fever virus (CSFV) infection. pEGFP-C1-NS3 transfection vs. pEGFP-C1 transfection was evaluated on Apoptosis rate (p=< 0.05). Expression of the CSFV NS3 protein in PK-15 cells induced a significantly higher apoptosis rate compared to control cells (43.4% vs 13.1%, p < 0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: